Neurobiology of Disease Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons during Glutamate-Induced Necrosis, Apoptosis, and Tolerance
نویسندگان
چکیده
Manus W. Ward,1* Heinrich J. Huber,1,2* Petronela Weisová,1 Heiko Düssmann,1 David G. Nicholls,3 and Jochen H. M. Prehn1 1Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin 2, Ireland, 2Siemens Medical Division, Siemens Ireland, Dublin 2, Ireland, and 3Buck Institute for Age Research, Mitochondrial Physiology, Novato, California 94945
منابع مشابه
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.
A failure of mitochondrial bioenergetics has been shown to be closely associated with the onset of apoptotic and necrotic neuronal injury. Here, we developed an automated computational model that interprets the single-cell fluorescence for tetramethylrhodamine methyl ester (TMRM) as a consequence of changes in either delta psi(m) or delta psi(p), thus allowing for the characterization of respon...
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